Genetic Cross Recommender
Tell us your goal. We solve the cross plan. Optimized for expected yield, inbreeding, time-to-target, and per-diem cost.
Available on Lab Pro ($79/mo billed yearly)
Colony graph · 247 candidate pairs
Top 3 plans
#1 M-187 × F-204
92#2 M-211 × F-198
84#3 M-156 × F-219
71Goal-driven, not pair-driven
Most colony tools ask you to pick the pair. The recommender flips that. You define the outcome you need and the recommender searches your colony for the cross plan that delivers it.
- Specify target genotype, target count, target date, and any constraints
- Define multi-locus goals (e.g. Cre+;flox/flox;Rosa26-tdTomato)
- Set the sex, the date you need them by, and the protocol they go on
- Set an inbreeding limit; plans that would pass a protocol's approved number are left out
- Specify soft preferences (minimize cost, maximize speed, balance both)
New cross plan
Pair scoring with auditable math
Every candidate plan gets a score that combines five factors. The factors are weighted by the preferences you set, and every component of the score is shown.
- Expected goal-genotype yield: Mendelian probability times litter size from your strain's history, or a cited default
- Inbreeding coefficient: computed via Wright's pedigree-traversal method
- Breeders: how many pairs the plan sets up, over up to three generations
- Time-to-target: gestation, wean, biopsy, and identify cycle for the strain
- Projected cost: cage demand times per-diem rate for the planned breeding window
- Each component is shown alongside the final score for full transparency
Pair score · M-187 × F-204
92Top-N ranked plans with full breeding tree
The recommender returns the five best plans, each with a breeding tree, expected timeline, projected pup counts, and a backup option in case a primary pair is retired.
- Top 5 ranked plans, sorted by score with side-by-side comparison
- Each plan shows the full breeding tree from current animals to the goal
- Expected dates for each step: pairing, first litter, weaning and genotyping
- A backup pair offered for each step, in case a breeder is lost
- Set up the first pairs from the plan, each in a cage you choose
- Cages and cost by month, with a CSV for grant budgets
M-187 × F-204
ETA 2026-06-22 · 14.2 pups expected
$1,840
M-211 × F-198
ETA 2026-06-29 · 11.6 pups expected
$2,120
M-156 × F-219
ETA 2026-07-04 · 9.8 pups expected
$2,400
Inbreeding-aware by default
The recommender uses your colony's full pedigree to compute inbreeding coefficient for every candidate pair. Pairs that exceed the configured threshold are excluded automatically.
- Wright's coefficient of inbreeding (F) computed from the colony's pedigree
- Configurable limit per organization (default F below 0.25, which leaves out full siblings)
- F is computed from every recorded generation of parents
- Threshold-violating pairs are excluded from results, not just flagged
- Override is supported for users who explicitly want a higher-F cross
Pedigree depth · every recorded generation
F = 0.063
below 0.125 threshold ✓
Fall back gracefully when no plan exists
When the colony cannot deliver the goal under the constraints, the recommender says so plainly. It surfaces the closest near-misses and identifies which constraint is binding.
- Clear no-result state with the binding constraint identified
- Closest near-miss plans shown with relaxation suggestions
- Names the allele no breeding animal carries when the colony cannot reach the goal
- Gives the earliest date that works when the deadline is too soon
- Never returns a 0% expected-yield plan as a top result
No viable plan under current constraints
Binding constraint: target date 2026-06-15
Try one of these
Plan crosses with rigor, not guesswork
Cross Recommender is included in every Lab Pro plan.